Research context and placement

Foundational in-vitro liver-toxicity modeling of endothelial barriers and hepatocyte interactions. It does not directly establish tissue repair or implanted-device host responses.

Boundary case: assigned to the closest interface for navigation. Read the rationale and cross-links together; the primary theme does not delimit the study. Placement of foundational work does not establish direct bioelectronic application.

Research overview and key contributions

The liver-toxicity model combines HepG2/C3A–GelMA tissue, sacrificially printed channels and HUVEC endothelium.

The endothelial layer delayed molecular permeation and improved viability relative to non-endothelialized controls.

Open challenges

Editorial question: does endothelial protection translate into accurate liver-toxicity prediction?

Comparison context

Match drug/exposure, endothelialization, cell source and permeability/viability readouts.

Related external research

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

DOI: 10.1038/nmat3357 ↗

Sacrificial carbohydrate-glass networks supported perfusable channels and primary rat hepatocyte function.

PubMed abstract read. Primary rat hepatocytes/perfusion and a HepG2/C3A toxicity-barrier model differ in cells, matrices and endpoints.

Abstract checked

Corresponding-author verification

Jungmok Seo: not a corresponding author

This record concerns Jungmok Seo’s correspondence designation. Author order or an asterisk alone is not treated as confirmation; this check is separate from verification of the research content.

Main-text review scope
The existing commentary is based on the following review: AIP landing-page abstract and Crossref abstract read; its long reference list was not counted as body access. Reading figure and correspondence information in this pass does not establish completion of a full in-depth article review.
Pending verification
Verify toxicant identity/dose, perfusion conditions, cell counts and supplements in school Chrome. The existing commentary is based on the following review: AIP landing-page abstract and Crossref abstract read; its long reference list was not counted as body access. Reading figure and correspondence information in this pass does not establish completion of a full in-depth article review.

COVERAGE & OUTREACH

Coverage and outreach

Links are checked for their relationship to this paper. Media publication does not establish independent reporting or additional experimental validation.

  • AIP Publishing · 2017-08-03 · Publisher feature

    Bioprinted Veins Reveal New Drug Diffusion Details ↗

    The release names the exact paper and authors, including Massa, Sakr, Seo and Shin, and discusses endothelial drug diffusion in the liver model.

    Body read Read the publisher release, date and concluding paper/author details. It is publisher-produced promotion.

  • ScienceDaily · 2017-08-04 · Release-based reporting / republication

    Bioprinted veins reveal new drug diffusion details ↗

    The journal reference explicitly gives DOI 10.1063/1.4994708, the matching title and authors.

    Body read Read the article and date. Its source credit explicitly identifies AIP material, so it is a release republication rather than independent reporting.

  • Cellular 3D · 2018-01-02 · Release-based reporting / republication

    Researchers Develop 3D Printed Liver Model for Accurate Drug Toxicity Testing ↗

    The short summary matches the vascularized liver-toxicity model and explicitly links the verified AIP release about paper 35.

    Body read Read the date, short body and source link. No independent reporting or experimental validation was established.

Channel coverage and search log for all 101 records →

Sources and verification scope

AIP landing-page abstract and Crossref abstract read; its long reference list was not counted as body access.