Tissue–biomaterial interface. Classification centers on tissue contact, mechanical adaptation and analyte transport.
A tissue-contacting material needs more than adhesion. It may also need to move with the body and allow selected molecules to pass through. This theme brings together hydrogel and bioadhesive design, tissue repair and studies of cell–material interactions.
Materials designed to establish and maintain contact with wet tissue.
Nature Communications, 17, 5526 (2026)
STAT, a quinone-mediated double-network hydrogel, bonded to wet porcine skin at 273 kPa lap-shear strength and stopped mouse liver bleeding within 10 s.
Advanced Science, 10(30), 2303651 (2023)
A tannic acid double-network hydrogel patch that self-heals, resists swelling and bonds to porcine skin (≈35.98 kPa); it stopped mouse liver bleeding in 10 s.
Biotechnology Journal, 16(12), 2100231 (2021)
A review of bioadhesives that add antimicrobial, cell-infiltrative, conductive, self-healing or stimuli-responsive functions for tissue healing and sensing.
How stiffness, toughness, recovery and swelling affect a material’s ability to accommodate tissue movement.
Biosensors & Bioelectronics, 255, 116257 (2024)
Nanoclay and carbon nanotube fillers set a 3D-printable hydrogel ink to 10–300 kPa modulus and about 20 S/m conductivity for a ring-shaped finger sensor.
Advanced Science, 10(12), 2207237 (2023)
A PVA/PAA hydrogel with tannic acid and carbon nanotube nanoconfinement resisted swelling, self-healed within 5 min, conducted ≈40 S m−1 and was 3D printable.
How molecules in body fluids reach a sensor, and how their transport can be controlled.
Advanced Materials, 38(19), e15767 (2026)
Sulfate and calcium treatment order tuned PVA–alginate hydrogel pores from 65 nm to 2.5 µm, setting glucose sensor ranges for sweat and interstitial fluid.
ACS Nano, 12 (2), 932-941 (2018)
A vacuum tip beneath stretchable superamphiphobic PDMS moved droplets and left 0.05–1.4 μL aliquots on wettable spots for glucose, uric acid and lactate assays.
Ways to shape and deliver materials for tissue repair and fabrication.
Advanced Materials, e74385 (2026)
A moldable PVA/gelatin/nanocellulose hydro-dough stopped calvarial sinus bleeding within 50 s and, with bone fragments, reached 34.80% BV/TV at 8 weeks.
Advanced Materials Technologies, 9(11), 2400060 (2024)
A robot-mounted depth camera guides in situ printing of multiple inks into wounds; spray mode covered a 10 cm × 10 cm area 12 times faster than extrusion.
Materials Science and Engineering R: Reports, 119, 1-35 (2017)
Review of tissue engineering hydrogels controlled in space and time, from micropatterning and 3D bioprinting to timed release, stiffening and degradation.
A provisional grouping for foundational materials or processes that may connect to this theme. It does not establish theme fit; each paper retains a rationale and ambiguity flag.
Advanced Materials Technologies, 9(10), 2400157 (2024)
A salting-out hydrogel ink kept gelation below room temperature for direct ink writing, yielding printed hydrogels with Young's moduli of 0.193–1.072 MPa.
Advanced Healthcare Materials, 8 (3), 1801146 (2019)
A pneumatic chip applied 1 Hz cyclic compression (0–20%) to cardiac fibroblasts in GelMA; 15–20% strain promoted myofibroblast activation, 5–10% did not.
Current Pharmaceutical Design, 24 (45), 5458-5470 (2018)
Review of biomaterial microarray platforms that screen cell responses to chemical and physical cues in 2D and 3D, and biosensors for organ-on-chip monitoring.
ACS Applied Materials & Interfaces, 10 (16), 13293-13303 (2018)
Stackable gas-driven bioreactors applied 0–42% cyclic compression to stem cells in 3D GelMA; 42% strain in 5% GelMA raised Runx2, ALP and calcium deposition.
Biomaterials, 153, 85-101 (2018)
Review of high-throughput platforms that screen cell responses to biomaterials and delivered molecules in 2D and 3D and analyze genes, glycans and proteins.
Nanoscale, 9(47), 18737-18752 (2017)
Titanium-coated nanogratings with pulsed stimulation raised MAP2-positive cells from human neural stem cells to 56.2% in 5 days, versus 24.6% on bare flat PUA.
Biomicrofluidics, 11 (4), 044109 (2017)
A bioprinted GelMA liver model with an endothelial-lined channel delayed dye diffusion and lessened acetaminophen-induced loss of HepG2/C3A metabolic activity.
Small, 13 (7), 1602865 (2017)
A superhydrophobic silver-dendrite track with a droplet stopper moved 1 µL droplets to a Raman spot for successive SERS reads; enhancement factor 6.3 × 10⁵.
ACS Applied Materials & Interfaces, 8 (28), 17763-17774 (2016)
Graphene oxide substrates with 5 μm grooves, ridges and nanoroughness increased neuronal differentiation of human neural stem cells without neurogenic factors.
Advanced Materials, 26 (41), 7043-7050 (2014)
Hydrogen-switchable Pd/Si nanowires held hanging culture drops for human stem cell spheroids that secreted more VEGF than spinner-flask or petri-dish spheroids.