Research context and placement

Foundational tissue mechanics: compression of cardiac fibroblasts in GelMA. The in-vitro fibrosis model is distinct from an implanted-device host response.

Boundary case: assigned to the closest interface for navigation. Read the rationale and cross-links together; the primary theme does not delimit the study. Placement of foundational work does not establish direct bioelectronic application.

Research overview and key contributions

The chip applies cyclic compression and cytokines to cardiac fibroblasts embedded in GelMA.

It relates deformation to fibrotic phenotype while considering myofibroblast maturity.

Open challenges

Editorial question: predictive validity for human myocardium and other loading modes remains unverified.

Comparison context

Editorial comparison: match strain direction, frequency, gel stiffness, maturity and cytokines.

Related external research

Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro

DOI: 10.7554/elife.22847 ↗

The external abstract combines strain and oxygen in human fibroblasts, contrasting with #52’s GelMA compression/cytokine axes.

Do not rank fibrosis effects without matched oxygen, cell origin and loading.

Abstract checked

Corresponding-author verification

Jungmok Seo: not a corresponding author

This record concerns Jungmok Seo’s correspondence designation. Author order or an asterisk alone is not treated as confirmation; this check is separate from verification of the research content.

  • Correspondence evidence source ↗

    Corresponding Author — Ali Khademhosseini; Corresponding Author — Su Ryon Shin

    complete publisher author details; two Corresponding Author labels · publisher_author_detail_read

Main-text review scope
Publisher and registered abstracts were read; main text and supplements remain unchecked.
Pending verification
Verify loading calibration, biological replicates and supplements in school Chrome.

COVERAGE & OUTREACH

Coverage and outreach

Links are checked for their relationship to this paper. Media publication does not establish independent reporting or additional experimental validation.

No related outreach link was verified against its body within these searches. This does not establish that none exists.

Channel coverage and search log for all 101 records →

Sources and verification scope

Publisher and registered abstracts were read; main text and supplements remain unchecked.